How do my blood vessels get clogged? Several things, including having diabetes, can increase your blood cholesterol too much. Cholesterol is a substance that is made by the body and used for many important functions. It is also found in some animal foods we eat. When cholesterol is too high, the insides of large blood vessels become clogged and narrowed. This problem is called atherosclerosis (ATH-uh-row-skluh-RO-sis).
Clogged and narrowed blood vessels make it harder for enough healthy blood to get to all parts of your body. This can cause one or more problems.

Healthy Blood Vessel

Clogged and Narrowed Blood Vessel